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Cassiopeia

Build Cassiopeia Mid

Runes, items & skill order

Mage

Patch 16.20

Customize your build
Role
Win rate46.27%
Pick rate1.08%
Ban rate1.04%
TierD
OPMetaLoL›Champions›Cassiopeia

All servers · Patch 16.20 · 2026-10-13 00:00 UTC · Data sources

Build Cassiopeia Mid

Keystone rune

Deathfire Touch

Sorcery + Precision

Skill priority

E → Q → W

View the level-by-level order

Compare win rates by rank

Choose a rank to load its own build and statistics. Win rates describe different player samples; they do not measure how easy a rank is.

RankWin rateCore build sample
Emerald+48.24%2,334
All ranks46.27%7,160
Iron——
Bronze——
Silver——
Gold——
Platinum——
Emerald——
Diamond48.86%638
Master——
Grandmaster——
Challenger——
Cassiopeia Runes Cassiopeia Mid Build
46.27% WR
Sorcery Primary
Precision Secondary
Stat Shards
Offense
Adaptive Force Attack Speed Ability Haste
Adaptive Force
Flex
Adaptive Force Movement Speed Health Scaling
Adaptive Force
Defense
Health Tenacity and Slow Resist Health Scaling
Health Scaling
Summoner Spells 46.27%
Flash Flash
Teleport Teleport

Items

Starting items
item 1056
item 2003
46.83% WR 28,308 matches
Most popular starting combination
Core items
item 6657
→
item 3040
→
item 3116
→
item 3009
53.48% WR 7,160 matches
Popular core combination
Fourth item options
item 3157
Zhonya's Hourglass 53.68% WR 3,245 matches
item 6653
Liandry's Torment 54.46% WR 2,657 matches
item 3089
Rabadon's Deathcap 56.68% WR 1,893 matches
item 3116
Rylai's Crystal Scepter 51.12% WR 1,477 matches
item 3135
Void Staff 52.08% WR 528 matches
Fifth item options
item 3089
Rabadon's Deathcap 51.89% WR 927 matches
item 3157
Zhonya's Hourglass 53.28% WR 687 matches
item 3135
Void Staff 53.57% WR 308 matches
item 6653
Liandry's Torment 56.02% WR 266 matches
item 3165
Morellonomicon 49.50% WR 202 matches
Sixth item options
item 3089
Rabadon's Deathcap 31.25% WR 16 matches
item 3157
Zhonya's Hourglass 40.00% WR 15 matches
item 3135
Void Staff 57.14% WR 14 matches
item 4629
Cosmic Drive 75.00% WR 8 matches
item 6653
Liandry's Torment 57.14% WR 7 matches

Skill priority

E
E
→
Q
Q
→
W
W
46.27% WR

Skill order

Most popular ability leveling order · source levels 1–15

Levels 1–5

Ability12345
Noxious BlastQ ·Q···
MiasmaW ··W··
Twin FangE E··EE
Petrifying GazeR ·····

Levels 6–10

Ability678910
Noxious BlastQ ··Q·Q
MiasmaW ·····
Twin FangE ·E·E·
Petrifying GazeR R····

Levels 11–15

Ability1112131415
Noxious BlastQ ·QQ··
MiasmaW ···WW
Twin FangE ·····
Petrifying GazeR R····
Q
Q Noxious Blast
2
8
10
12
13
W
W Miasma
3
14
15
E
E Twin Fang
1
4
5
7
9
R
R Petrifying Gaze
6
11
passive
P Serpentine Grace

Champion win rate against each opponent, for the selected role and rank. Small samples are less reliable.

Cassiopeia Mid build guide: runes, items and skill order

This Cassiopeia Mid build covers League of Legends patch 16.20. Compare the selected runes, starting items and core purchases before the match, then adapt your later purchases to enemy damage and defenses. The source recommendations use the All ranks filter across all servers.

For Cassiopeia runes, this setup uses Deathfire Touch with Precision as the secondary path. Check the highlighted stat shards as well: they are part of the rune page, not extra items. Hover or tap a rune to read its effect before deciding whether it suits your matchup.

The displayed Cassiopeia skill order starts with E and prioritizes E → Q → W. The level-by-level grid covers the first 15 levels supplied by the source. Follow that sequence as a reference while accounting for what your lane or team needs. Item win rates describe completed purchases and should be read alongside their game counts.

Which items should you build on Cassiopeia Mid?

The most popular core items in this Cassiopeia Mid build are Rod of Ages → Seraph's Embrace → Rylai's Crystal Scepter. Check starting items and boots separately, then compare later item options against the enemy team. This is a reference for patch 16.20, not a fixed purchase order for every match.

Which runes should you choose for Cassiopeia Mid?

For the selected All ranks rank filter, the rune page uses Deathfire Touch with Precision. Review each rune tooltip and the selected stat shards before entering champion select.

How do you compare Cassiopeia builds by rank?

Use the rank selector to view a separate build and win rate for Iron, Bronze, Silver, Gold, Platinum, Emerald, Diamond, Master, Grandmaster or Challenger. Keep the same role when comparing. A small sample is less reliable, and a higher win rate alone does not prove a better build.

How this build works

Rune choice

This setup pairs Sorcery with Precision and uses Deathfire Touch as its keystone. The highlighted runes and shards belong to this imported setup; inspect an icon to read its effect.

Core purchases

The most popular core combination in the source is Rod of Ages → Seraph's Embrace → Rylai's Crystal Scepter. Treat it as a starting point: choose defensive or penetration options for the opponents you are facing.

Read the sample

The core combination has an observed win rate of 53.48% across 7,160 games. These are games that reached this purchase combination, not all games played by the champion. A completed build can appear stronger because winning players can afford more items.

How we select and update builds →

How to play Cassiopeia: abilities and build guide

Learn Cassiopeia abilities and prepare your first games. Find builds for each supported role.

Read the guide

About Cassiopeia

Cassiopeia is a deadly creature bent on manipulating others to her sinister will. Youngest and most beautiful daughter of the noble Du Couteau family of Noxus, she ventured deep into the crypts beneath Shurima in search of ancient power. There, she was bitten by a gruesome tomb guardian, whose venom transformed her into a viper-like predator. Cunning and agile, Cassiopeia now slithers under the veil of night, petrifying her enemies with her baleful gaze.